Open Access<p>Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting – Part II: In vitro and in vivo Kinetics Study</p>
Author(s) -
Aya Sebak,
Iman Gomaa,
Aliaa Nabil ElMeshad,
Mahmoud Hussien Farag,
HansGeorg Breitinger,
Mahmoud H. AbdelKader
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s273721
Subject(s) - clusterin , endocytosis , in vivo , in vitro , vitronectin , microbiology and biotechnology , receptor , chemistry , biophysics , integrin , biology , biochemistry , apoptosis
Nanoparticles (NPs), upon introduction to the biological systems, become wrapped by serum and cellular proteins constituting the protein corona (PC). This PC contributes largely to the NPs' interaction with the biological systems and their subsequent functions. On the one hand, PC can decrease the efficiency of targeting by directing the NPs to the reticuloendothelial system (RES) or by masking the active targeting moieties and decreasing their ability to bind to their target receptors. On the other hand, some components of PC have offered hopes for achieving endogenous targeting.