Open Access<p>Nano-Silicate-Reinforced and SDF-1α-Loaded Gelatin-Methacryloyl Hydrogel for Bone Tissue Engineering</p>
Author(s) -
Zhe Shi,
Yan Xu,
Ruzha Mulatibieke,
Qiang Zhong,
Xuran Pan,
Yuhang Chen,
Qi Lian,
Xin Luo,
Qingan Zhu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s270681
Subject(s) - self healing hydrogels , gelatin , biomedical engineering , materials science , homing (biology) , tissue engineering , stromal cell , chemistry , pathology , medicine , polymer chemistry , ecology , biochemistry , biology
Autologous bone grafts are the gold standard for treating bone defects. However, limited bone supply and morbidity at the donor site restrict its extensive use. Therefore, developing bone graft materials as an alternative to autologous grafts has gained considerable attention. Injectable hydrogels endowed with osteogenic potential have the ability to fill irregular bone defects using minimally invasive procedures and have thus been attracting researchers' attention. However, from a clinical perspective, most fabrication methods employed for the current injectable osteogenic hydrogels are difficult and inconvenient. In the current study, we fabricated an injectable osteogenic hydrogel using a simple and convenient strategy.