Open Access<p>Preparation and Evaluation of Recombinant Human Erythropoietin Loaded Tween 80-Albumin Nanoparticle for Traumatic Brain Injury Treatment</p>
Author(s) -
Yuanfeng Xue,
Jingzhong Ding,
Yulong Liu,
Yuchun Pan,
Penglai Zhao,
Zhiwen Ren,
Jian Xu,
Liangliang Ye,
Ying Xu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s264025
Subject(s) - erythropoietin , in vivo , traumatic brain injury , glial fibrillary acidic protein , albumin , pharmacology , zeta potential , blood–brain barrier , chemistry , in vitro , biocompatibility , medicine , materials science , nanoparticle , immunology , biochemistry , immunohistochemistry , nanotechnology , central nervous system , biology , psychiatry , microbiology and biotechnology , organic chemistry
Traumatic brain injury (TBI) is a serious health problem with few available treatment options. Rh-erythropoietin (rh-EPO) is a potential therapeutic drug for TBI, but it cannot cross the blood-brain barrier (BBB) directly. In this regard, a novel strategy to deliver rh-EPO for enhanced TBI treatment is via the development of Tween 80 modified albumin nanoparticles using electrostatic spray technology.