Open Access<p>Preparation and Evaluation of Cabazitaxel-Loaded Bovine Serum Albumin Nanoparticles for Prostate Cancer</p>
Author(s) -
Wu Zhong,
Fang Xie,
Liang Wang,
Guoqing Zhang,
Zhang Hai
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s258856
Subject(s) - in vivo , pharmacokinetics , chemistry , pharmacology , cabazitaxel , biodistribution , bovine serum albumin , docetaxel , prostate cancer , distribution (mathematics) , drug delivery , in vitro , cancer , medicine , chromatography , biochemistry , mathematical analysis , microbiology and biotechnology , mathematics , organic chemistry , biology , androgen deprivation therapy
Cabazitaxel (CBZ) is a new taxane-based antitumor drug approved by the FDA for the treatment of prostate cancer, especially for patients with advanced prostate cancer for whom docetaxel is ineffective or causes aggravation. However, Tween 80 injection can cause serious allergic reactions, and CBZ itself has strong toxicity, adverse reactions, and poor tumor selectivity, which greatly limits its clinical applications. Therefore, the CBZ-loaded bovine serum albumin nanoparticles (CBZ-BSA-Gd-NPs) were developed to overcome the allergenic response of Tween 80 and realize the integration of diagnosis and treatment.