Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations | Zendy

Yue Zhang | Zendy; Rui Zhang | Zendy; Upulitha Eranka Illangakoon | Zendy; A. H. Harker | Zendy; Christopher Thrasivoulou | Zendy; Maryam Parhizkar | Zendy; Mohan Edirisinghe | Zendy; Chaojie Luo | Zendy

Open Access

<p>Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations</p>

Author(s) -

Yue Zhang,

Rui Zhang,

Upulitha Eranka Illangakoon,

A. H. Harker,

Christopher Thrasivoulou,

Maryam Parhizkar,

Mohan Edirisinghe,

Chaojie Luo

Publication year - 2020

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s257353

Subject(s) - nanoparticle , materials science , crystallinity , plga , copolymer , chemical engineering , fourier transform infrared spectroscopy , bioavailability , drug carrier , nanocapsules , dispersity , controlled release , polymer , dissolution testing , drug delivery , nanotechnology , nuclear chemistry , chemistry , polymer chemistry , ethyl cellulose , pharmacology , medicine , engineering , composite material

Developing oral formulations to enable effective release of poorly water-soluble drugs like progesterone is a major challenge in pharmaceutics. Coaxial electrospray can generate drug-loaded nanoparticles of strategic compositions and configurations to enhance physiological dissolution and bioavailability of poorly water-soluble drug progesterone.

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