Open Access<p>Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations</p>
Author(s) -
Yue Zhang,
Rui Zhang,
Upulitha Eranka Illangakoon,
A. H. Harker,
Christopher Thrasivoulou,
Maryam Parhizkar,
Mohan Edirisinghe,
C. J. Luo
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s257353
Subject(s) - nanoparticle , materials science , crystallinity , plga , copolymer , chemical engineering , fourier transform infrared spectroscopy , bioavailability , drug carrier , nanocapsules , dispersity , controlled release , polymer , dissolution testing , drug delivery , nanotechnology , nuclear chemistry , chemistry , polymer chemistry , ethyl cellulose , pharmacology , medicine , engineering , composite material
Developing oral formulations to enable effective release of poorly water-soluble drugs like progesterone is a major challenge in pharmaceutics. Coaxial electrospray can generate drug-loaded nanoparticles of strategic compositions and configurations to enhance physiological dissolution and bioavailability of poorly water-soluble drug progesterone.