Efficient miRNA Inhibitor with GO-PEI Nanosheets for Osteosarcoma Suppression by Targeting PTEN | Zendy

Lingling Ou | Zendy; Haiyingjie Lin | Zendy; Yuwei Song | Zendy; Guoqiang Tan | Zendy; Xiujuan Gui | Zendy; Jinyuan Li | Zendy; Xiaoting Chen | Zendy; Zhendong Deng | Zendy; Shaoqiang Lin | Zendy

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<p>Efficient miRNA Inhibitor with GO-PEI Nanosheets for Osteosarcoma Suppression by Targeting PTEN</p>

Author(s) -

Lingling Ou,

Haiyingjie Lin,

Yuwei Song,

Guoqiang Tan,

Xiujuan Gui,

Jinyuan Li,

Xiaoting Chen,

Zhendong Deng,

Shaoqiang Lin

Publication year - 2020

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s257084

Subject(s) - osteosarcoma , pten , tensin , cancer research , apoptosis , microrna , cytotoxicity , chemistry , microbiology and biotechnology , biology , pi3k/akt/mtor pathway , biochemistry , in vitro , gene

Gene therapy is considered a novel way to treat osteosarcoma, and microRNAs are potential therapeutic targets for osteosarcoma. miR-214 has been found to promote osteosarcoma aggression and metastasis. Graphene oxide (GO) is widely used for gene delivery for the distinct physiochemical properties and minimal cytotoxicity.

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