Open Access<p>Efficient miRNA Inhibitor with GO-PEI Nanosheets for Osteosarcoma Suppression by Targeting PTEN</p>
Author(s) -
Lingling Ou,
Haiyingjie Lin,
Yuwei Song,
Guoqiang Tan,
Xiujuan Gui,
Jinyuan Li,
Marc E. Rothenberg,
Zhendong Deng,
Shaoqiang Lin
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s257084
Subject(s) - osteosarcoma , pten , tensin , cancer research , apoptosis , microrna , cytotoxicity , chemistry , microbiology and biotechnology , biology , pi3k/akt/mtor pathway , biochemistry , in vitro , gene
Gene therapy is considered a novel way to treat osteosarcoma, and microRNAs are potential therapeutic targets for osteosarcoma. miR-214 has been found to promote osteosarcoma aggression and metastasis. Graphene oxide (GO) is widely used for gene delivery for the distinct physiochemical properties and minimal cytotoxicity.