Open Access<p>Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO-1/NF-kB Signalling Pathway</p>
Author(s) -
Pingping Li,
Syed Nasir Abbas Bukhari,
Tahseen Mohsan Khan,
Renukaradhya Chitti,
Davan B Bevoor,
Anand R Hiremath,
Nagaraja Sreeharsha,
Yogendra Singh,
Kumar Shiva Gubbiyappa
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s256494
Subject(s) - diabetic nephropathy , streptozotocin , apigenin , pharmacology , nicotinamide , diabetes mellitus , chemistry , cancer research , medicine , biochemistry , endocrinology , enzyme , flavonoid , antioxidant
Apigenin is known to have a broad-spectrum efficacy in oxidative stress and conditions due to inflammation, although weak absorption, fast metabolic rate and a fast elimination (systemic) limit the pharmacological efficacy of this drug. Hence, we propose the usage of highly bioavailable Apigenin-solid lipid nanoparticles (SLNPs) to recognize such limitations. The defensive function of Apigenin-SLNPs on renal damage induced by streptozotocin (STZ) in animals was studied.