Open Access<p>Silica Nanocapsules with Different Sizes and Physicochemical Properties as Suitable Nanocarriers for Uptake in T-Cells</p>
Author(s) -
Raweewan Thiramanas,
Shuai Jiang,
Johanna Simon,
Katharina Landfester,
Volker Mailänder
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s246322
Subject(s) - nanocarriers , flow cytometry , nanocapsules , biocompatibility , toxicity , confocal microscopy , biophysics , cd8 , materials science , chemistry , nanotechnology , immune system , microbiology and biotechnology , biology , drug delivery , nanoparticle , immunology , metallurgy , organic chemistry
Adoptive T-cell immunotherapy emerged as a powerful and promising cancer therapy, as the problem regarding the immuno-reaction between different donors and recipients can be avoided. However, this approach is challenging. After long cultivation and expansion under laboratory media conditions, T-cells are losing their viability and function due to immune checkpoint proteins, leading to decreased efficiency in killing cancer cells. Therefore, a new strategy to improve T-cell survival and function is needed. With the advantages of nanotechnology and the biocompatibility of silica-based material, silica nanocapsules (SiNCs) provide an ideal delivery system to transport therapeutic biomolecules to T-cells. Up to now, there is a lack of cellular uptake studies of nanocarriers towards T-cells.