Open Access<p>Verteporfin-Loaded Anisotropic Poly(Beta-Amino Ester)-Based Micelles Demonstrate Brain Cancer-Selective Cytotoxicity and Enhanced Pharmacokinetics</p>
Author(s) -
James G. Shamul,
Sagar Shah,
Jayoung Kim,
Paula Schiapparelli,
Carla Vazquez-Ramos,
Ben J Lee,
Kisha Patel,
Alyssa Shin,
Alfredo QuiñonesHinojosa,
Jordan J. Green
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s231167
Subject(s) - micelle , ethylene glycol , verteporfin , cytotoxicity , peg ratio , biophysics , materials science , cancer research , chemistry , pharmacology , in vitro , medicine , biochemistry , biology , organic chemistry , aqueous solution , retinal , finance , choroidal neovascularization , economics
Nanomedicine can improve traditional therapies by enhancing the controlled release of drugs at targeted tissues in the body. However, there still exists disease- and therapy-specific barriers that limit the efficacy of such treatments. A major challenge in developing effective therapies for one of the most aggressive brain tumors, glioblastoma (GBM), is affecting brain cancer cells while avoiding damage to the surrounding healthy brain parenchyma. Here, we developed poly(ethylene glycol) (PEG)-poly(beta-amino ester) (PBAE) (PEG-PBAE)-based micelles encapsulating verteporfin (VP) to increase tumor-specific targeting.