Open Access<p>A Protein Corona Adsorbed to a Bacterial Magnetosome Affects Its Cellular Uptake</p>
Author(s) -
Wenjia Lai,
Dan Li,
Qingsong Wang,
Xiaohui Nan,
Zhichu Xiang,
Yan Ma,
Ying Liu,
Jiankui Chen,
Jie Tian,
Qiaojun Fang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s220082
Subject(s) - magnetosome , magnetotactic bacteria , internalization , biophysics , bacterial cell structure , chemistry , corona (planetary geology) , magnetic nanoparticles , microbiology and biotechnology , nanoparticle , materials science , nanotechnology , cell , bacteria , biology , biochemistry , genetics , astrobiology , venus
It is well known that when exposed to human blood plasma, nanoparticles are predominantly coated by a layer of proteins, forming a corona that will mediate the subsequent cell interactions. Magnetosomes are protein-rich membrane nanoparticles which are synthesized by magnetic bacteria; these have gained a lot of attention owing to their unique magnetic and biochemical characteristics. Nevertheless, whether bacterial magnetosomes have a corona after interacting with the plasma, and how such a corona affects nanoparticle-cell interactions is yet to be elucidated. The aim of this study was to characterize corona formation around a bacterial magnetosome and to assess the functional consequences.