Open Access<p>Delivering amoxicillin at the infection site – a rational design through lipid nanoparticles</p>
Author(s) -
Daniela Lopes,
Rita Maria Pinto,
Sofia A. Costa Lima,
Tiago dos Santos,
Bruno Sarmento,
Cláudia Nunes
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s193992
Subject(s) - amoxicillin , nanoparticle , rational design , pharmacology , materials science , nanotechnology , medicine , chemistry , antibiotics , biochemistry
Amoxicillin is a commonly used antibiotic, although degraded by the acidic pH of the stomach. This is an important limitation for the treatment of Helicobacter pylori infections. The purpose of this work was to encapsulate amoxicillin in lipid nanoparticles, increasing the retention time at the site of infection (gastric mucosa), while protecting the drug from the harsh conditions of the stomach lumen.