Open Access<p>Nematicidal activity of silver nanoparticles from the fungus <em>Duddingtonia flagrans</em></p>
Author(s) -
Anna Claudia Mombrini Silva Barbosa,
Laryssa Pinheiro Costa Silva,
Carolina Magri Ferraz,
Fernando Luiz Tobias,
Jackson Víctor de Araújo,
B. Loureiro,
Gracilene Maria Almeida Muniz Braga,
Francielle Bosi Rodrigues Veloso,
Filippe Elias de Freitas Soares,
Márcio Fronza,
Fábio Ribeiro Braga
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s193679
Subject(s) - anthelmintic , nematode , microbiology and biotechnology , silver nanoparticle , biology , fungus , in vitro , immune system , materials science , nanoparticle , nanotechnology , biochemistry , immunology , botany , ecology
Helminth parasites cause morbidity and mortality in both humans and animals. Most anthelmintic drugs used in the treatment of parasitic nematode infections act on target proteins or regulate the electrical activity of neurons and muscles. In this way, it can lead to paralysis, starvation, immune attack, and expulsion of the worm. However, current anthelmintics have some limitations that include a limited spectrum of activity across species and the threat of drug resistance, which highlights the need for new drugs for human and veterinary medicine.