Open AccessPutative Involvement of Cytokine Modulation in the Development of Perioperative Neurocognitive Disorders
Author(s) -
Christopher Pereira,
Melanie Dani,
Simon D Taylor-Robinson,
Michael Fertleman
Publication year - 2022
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s364954
Subject(s) - medicine , neurocognitive , neuroinflammation , cytokine , perioperative , delirium , inflammation , interleukin 6 , cerebrospinal fluid , neuroscience , immunology , bioinformatics , anesthesia , intensive care medicine , pathology , cognition , psychiatry , psychology , biology
Following surgery, local cytokine-driven inflammation occurs, as part of the normal healing process. Cytokines in the central nervous system such as IL-6 and IL-8 may also be elevated. These cytokine changes likely contribute to neuroinflammation, but the complex mechanisms through which this occurs are incompletely understood. It may be that perioperative changes in pro- and anti-inflammatory cytokines have a role in the development of perioperative neurocognitive disorders (PND), such as post-operative delirium (POD). This review considers the current evidence regarding perioperative cytokine changes in the blood and cerebrospinal fluid (CSF), as well as considering the potential for cytokine-altering therapies to prevent and treat PND.