Putative Involvement of Cytokine Modulation in the Development of Perioperative Neurocognitive Disorders | Zendy

Christopher Pereira | Zendy; Melanie Dani | Zendy; Simon D. TaylorRobinson | Zendy; Michael Fertleman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Putative Involvement of Cytokine Modulation in the Development of Perioperative Neurocognitive Disorders

Author(s) -

Christopher Pereira,

Melanie Dani,

Simon D. TaylorRobinson,

Michael Fertleman

Publication year - 2022

Publication title -

international journal of general medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.722

H-Index - 36

ISSN - 1178-7074

DOI - 10.2147/ijgm.s364954

Subject(s) - medicine , neurocognitive , neuroinflammation , cytokine , perioperative , delirium , inflammation , interleukin 6 , cerebrospinal fluid , neuroscience , immunology , bioinformatics , anesthesia , intensive care medicine , pathology , cognition , psychiatry , psychology , biology

Following surgery, local cytokine-driven inflammation occurs, as part of the normal healing process. Cytokines in the central nervous system such as IL-6 and IL-8 may also be elevated. These cytokine changes likely contribute to neuroinflammation, but the complex mechanisms through which this occurs are incompletely understood. It may be that perioperative changes in pro- and anti-inflammatory cytokines have a role in the development of perioperative neurocognitive disorders (PND), such as post-operative delirium (POD). This review considers the current evidence regarding perioperative cytokine changes in the blood and cerebrospinal fluid (CSF), as well as considering the potential for cytokine-altering therapies to prevent and treat PND.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research