Open AccessDevelopment and Validation of an HPLC-UV Method for Quantitation of Linezolid: Application to Resistance Study Using in vitro PK/PD Model
Author(s) -
Yang Guang,
Yisong Yan,
Jun Mao,
Huiping Liu,
Mingtao Chen,
Na Zhang,
Yaowen Li,
Jiangjun Gu,
Xiaohui Huang
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s343200
Subject(s) - linezolid , formic acid , chromatography , bioavailability , high performance liquid chromatography , pharmacokinetics , in vitro , chemistry , absorption (acoustics) , staphylococcus aureus , pharmacology , medicine , bacteria , materials science , biology , vancomycin , biochemistry , composite material , genetics
Linezolid (LNZ), an oxazolidinone antibiotic, has 100% oral bioavailability and favorable activities against gram-positive pathogens. The in vitro PK/PD model was developed based on concentrations obtained with routine doses in humans can be used to guide dose optimization in the clinic.