Open Access<p>Plasmid-Mediated AmpC β-Lactamase <em>CITM</em> and <em>DHAM</em> Genes Among Gram-Negative Clinical Isolates</p>
Author(s) -
Subhas Chandra Aryal,
Milan Kumar Upreti,
Anil Kumar Sah,
Mehraj Ansari,
Krishus Nepal,
Binod Dhungel,
Nabaraj Adhikari,
Binod Lekhak,
Komal Raj Rijal
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s284751
Subject(s) - cefoxitin , gram , microbiology and biotechnology , pseudomonas aeruginosa , clavulanic acid , agar diffusion test , biology , antibiotic resistance , multiple drug resistance , antibiotics , cephalosporin , gram negative bacteria , gene , polymerase chain reaction , plasmid , bacteria , escherichia coli , amoxicillin , genetics , staphylococcus aureus
Antibiotic resistance mediated by the production of extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases is posing a serious threat in the management of the infections caused by Gram-negative pathogens. The aim of this study was to determine the prevalence of two AmpC β-lactamases genes, bla CITM and bla DHAM , in Gram-negative bacterial isolates.