Open Access<p>Efficacy of combinations of colistin with other antimicrobials involves membrane fluidity and efflux machinery</p>
Author(s) -
Eva Sanchez Armengol,
Òscar Domènech,
Ester Fusté,
Isabel Pérez-Guillén,
JH Borrell,
Josep M. Sierra,
Miguel Viñas
Publication year - 2019
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s207844
Subject(s) - colistin , efflux , antimicrobial , microbiology and biotechnology , pseudomonas aeruginosa , bacteria , acridine orange , biology , acinetobacter baumannii , pharmacology , chemistry , biochemistry , apoptosis , genetics
Despite its use was abandoned several decades ago, the polycationic peptide colistin has become the last hope to treat severe infections caused by multidrug-resistant Gram-negative bacteria. Thus, the development of colistin resistance may seriously compromise the efficacy of treatment. Moreover, colistin has high toxicity being dose dependent. A potentially effective strategy to avoid resistance may be to combine colistin with other antimicrobials. This may help in the rescue of old antimicrobials and in reducing toxic undesired effects.