Open Access<p>Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review</p>
Author(s) -
Georgios Tsokolas,
Konstantinos T Tsaousis,
Vasilios F. Diakonis,
Artemis Matsou,
Straton Tyradellis
Publication year - 2020
Publication title -
eye and brain
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.017
H-Index - 15
ISSN - 1179-2744
DOI - 10.2147/eb.s193026
Subject(s) - medicine , ophthalmology , retinal , optical coherence tomography , macular degeneration , optic neuropathy , diabetic retinopathy , multiple sclerosis , optic nerve , diabetes mellitus , psychiatry , endocrinology
Optical coherence tomography angiography (OCT-A) has emerged as a novel, fast, safe and non-invasive imaging technique of analyzing the retinal and choroidal microvasculature in vivo. OCT-A captures multiple sequential B-scans performed repeatedly over a specific retinal area at high speed, thus enabling the composition of a vascular map with areas of contrast change (high flow zones) and areas of steady contrast (slow or no flow zones). It therefore provides unique insight into the exact retinal or choroidal layer and location at which abnormal blood flow develops. OCTA has evolved into a useful tool for understanding a number of retinal pathologies such as diabetic retinopathy, age-related macular degeneration, central serous chorioretinopathy, vascular occlusions, macular telangiectasia and choroidal neovascular membranes of other causes. OCT-A technology is also increasingly being used in the evaluation of optic disc perfusion and has been suggested as a valuable tool in the early detection of glaucomatous damage and monitoring progression.