Open AccessAntihyperglycemic Activity of TLC Isolates from the Leaves of Aloe megalacantha Baker in Streptozotocin-Induced Diabetic Mice
Author(s) -
Tsgabu Yohannes Araya,
Aman Karim,
Gebremedhin Solomon Hailu,
Gomathi Periasamy,
Getu Kahsay
Publication year - 2021
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s288313
Subject(s) - streptozotocin , exudate , diabetes mellitus , thin layer chromatography , traditional medicine , insulin , in vivo , medicine , obesity , pharmacology , chemistry , biology , endocrinology , chromatography , microbiology and biotechnology , pathology
Diabetes mellitus (DM) is a group of metabolic disorders that are characterized by hyperglycemia which results from defects in insulin release or its efficient use by the human body. Although significant progress has been made to manage DM and related complications, it remains a major global health problem. To this end, the search for new antidiabetic drugs from traditionally claimed medicinal plants is important. Aloe megalacantha Baker is an endemic plant used traditionally to treat diabetes in Ethiopia. This study aimed to investigate antidiabetic activity of isolates from the leaf of A. megalacantha Baker in streptozotocin-induced diabetic mice.