Open AccessSynthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations
Author(s) -
Sajjad Ahmad,
Mater H. Mahnashi,
Bandar A. Alyami,
Yahya S. Alqahtani,
Farhat Ullah,
Muhammad Ayaz,
Muhammad Tariq,
Abdul Sadiq,
Umer Rashid
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s292826
Subject(s) - michael reaction , in vivo , chemistry , stereochemistry , in vitro , adduct , maleimide , pharmacology , biochemistry , organic chemistry , medicine , biology , microbiology and biotechnology , catalysis
Organocatalytic asymmetric Michael addition is a strong approach for C-C bond formation. The objective of the study is to design molecules by exploiting the efficiency of Michael Adducts. We proceeded with the synthesis of Michael adducts by tailoring the substitution pattern on maleimide and trans-β-nitro styrene as Michael acceptors. The synthesized compounds were evaluated for dual cyclooxygenases (COX) and lipoxygenase (LOX) inhibition.