Open AccessSimultaneous Quantitative Analysis of Six Proton-Pump Inhibitors with a Single Marker and Evaluation of Stability of Investigated Drugs in Polypropylene Syringes for Continuous Infusion Use
Author(s) -
Fuchao Chen,
Xingkang He,
Baoxia Fang,
Sicen Wang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s279302
Subject(s) - esomeprazole , chemistry , lansoprazole , rabeprazole , pantoprazole , chromatography , quantitative analysis (chemistry) , dosage form , potassium , omeprazole , proton pump inhibitor , pharmacology , medicine , biochemistry , organic chemistry , anatomy
We developed and validated a simple, convenient and reproducible method for simultaneous estimation of six proton-pump inhibitors (PPIs), omeprazole (OPZ), esomeprazole (EOPZ), lansoprazole (LPZ), pantoprazole (PPZ), rabeprazole (RPZ) and ilaprazole (IPZ) in pharmaceutical dosage forms by a single marker. Meanwhile, the stability of the cited PPIs in 0.9% sodium chloride injection stored in polypropylene syringes up to 48 hours for continuous infusion use was investigated.