Open Access<p>Evaluation of the Effect of <em>Hypericum triquetrifolium</em> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF</p>
Author(s) -
Karem H. Alzoubi,
Laila Abdel-Hafiz,
Omar F. Khabour,
Tamam ElElimat,
Mohammad A. Alzubi,
Feras Q. Alali
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s278153
Subject(s) - hypericum perforatum , chronic stress , hippocampus , hypericum , memory impairment , antidepressant , oxidative stress , pharmacology , hippocampal formation , medicine , behavioural despair test , psychology , neurotrophic factors , neuroscience , cognition , traditional medicine , receptor
Chronic psychosocial stress impairs memory function and leads to a depression-like phenotype induced by a persistent status of oxidative stress. Hypericum perforatum L. (St. John's wort) is widely used to relieve symptoms of anxiety and depression; however, its long-term use is associated with adverse effects. Hypericum triquetrifolium Turra is closely related to H. perforatum . Both plants belong to Hypericaceae family and share many biologically active compounds. Previous work by our group showed that methanolic extracts of H. triquetrifolium have potent antioxidant activity as well as high hypericin content, a component that proved to have stress-relieving and antidepressant effects by other studies. Therefore, we hypothesized that H. triquetrifolium would reduce stress-induced cognitive impairment in a rat model of chronic stress.