Open Access<p>Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways</p>
Author(s) -
Yanran Huang,
Jin Chen,
Shen Hsi Yang,
Tao Tan,
Nan Wang,
Yuping Wang,
Lulu Zhang,
Chunmei Yang,
Huakun Huang,
Jinyong Luo,
Xingguang Luο
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s277160
Subject(s) - mtt assay , osteosarcoma , flow cytometry , apoptosis , wnt signaling pathway , pi3k/akt/mtor pathway , protein kinase b , chemistry , cancer research , cell growth , microbiology and biotechnology , gentamicin protection assay , signal transduction , biology , western blot , biochemistry , gene
Osteosarcoma (OS) is a primary bone tumor associated with locally aggressive growth and early metastatic potential that typically occurs in children and adolescents. Chinese traditional medicine Cinnamomum cassia Presl has been shown to have significant tumor-killing effect, in which cinnamaldehyde (CA) is the main active ingredient.