Open Access<p>Cyanidin-3-O-Glucoside Improves Colonic Motility During Severe Acute Pancreatitis by Inhibiting the H<sub>2</sub>S-Regulated AMPK/mTOR Pathway</p>
Author(s) -
Wei Lian,
Wensheng Chen
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s256450
Subject(s) - ampk , pi3k/akt/mtor pathway , motility , amp activated protein kinase , acute pancreatitis , medicine , chemistry , endocrinology , gastroenterology , pharmacology , protein kinase a , signal transduction , biochemistry , kinase , biology , microbiology and biotechnology
Cyanidin-3-O-glucoside (C3G) is an important anthocyanin that can modulate digestive system functioning. Inflammation associated with severe acute pancreatitis (SAP) induces H 2 S production, which impairs the gastrointestinal (GI) system. We investigated the effects of C3G in attenuating SAP-associated colonic motility loss by examining the H 2 S level and activity of AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway.