Open Access<p>Validated Microwell-Based Spectrofluorimetric Method for Quantification of Ravidasvir (New Anti-Chronic Hepatitis C Virus-GT4) in Rat Plasma and Its Application to Pharmacokinetic Study</p>
Author(s) -
Mohamed M. Hefnawy,
Mona M. AlShehri,
Sara T. Al-Rashood,
Sherif F. Hammad,
Mohammed M. Alanazi,
Nawaf A. Alsaif,
Mostafa Mohammed,
Ahmad J. Obaidullah,
Manal A. El-Gendy
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s237949
Subject(s) - bioanalysis , pharmacokinetics , protein precipitation , chromatography , food and drug administration , chemistry , detection limit , tolerability , ns5a , hepatitis c virus , pharmacology , virus , virology , human plasma , medicine , hepacivirus , adverse effect
Ravidasvir (RAV) has been regarded as a potent new NS5A inhibitor with a magnificent safety and tolerability in the management of genotype 4 hepatitis C virus (HCV) patients. Suitable analytical techniques are needed for the measurement of RAV in different biological matrices.