Open AccessThe Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation
Author(s) -
Zhiyuan Chen,
Yi Zhang,
Jing Wu,
Xiang Gao,
Chunling Huang,
YanHui Lin,
Xiaoting Xu,
Yan Li
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s295329
Subject(s) - medicine , mechanical ventilation , pulmonary disease , lung , copd , obstructive lung disease , mechanism (biology) , inflammatory response , anesthesia , inflammation , philosophy , epistemology
Penehyclidine hydrochloride is a selective antagonist of M1 and M3 receptors. Clinical studies suggest that it is a potential drug for the treatment of chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effect of penehyclidine hydrochloride on the inflammatory response of lung tissue during mechanical ventilation in rats with COPD and explore the role of the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) signaling pathway.