Open AccessDetection of Cell-Dissociated Non-Typeable Haemophilus influenzae in the Airways of Patients with Chronic Obstructive Pulmonary Disease
Author(s) -
Samantha Thulborn,
Alessandro Ceroni,
Koirobi Haldar,
Vijay Mistry,
Jennifer Cane,
Christopher E. Brightling,
Michael R. Barer,
Mona Bafadhel
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s247130
Subject(s) - haemophilus influenzae , sputum , copd , medicine , immunology , exacerbation , inflammation , cell , spirometry , respiratory disease , microbiology and biotechnology , lung , pathology , asthma , biology , antibiotics , tuberculosis , genetics
Non-typeable Haemophilus influenzae (NTHi) is the most commonly found pathogen in the lower respiratory airways of patients with COPD. NTHi is predominantly regarded as an intracellular pathogen; however, like most pathogens, it can exist and co-exist in two broad forms: cell-associated (intracellularly or adhered to cells) or cell-dissociated (biofilm dispersed or planktonic). We sought to investigate if cell-dissociated NTHi can be detected from the sputum of COPD patients and assess this relationship to disease severity and airway inflammation.