Open Access<p>Serum Alpha-1 Antitrypsin Levels and the Clinical Course of Chronic Obstructive Pulmonary Disease</p>
Author(s) -
Nozomu Takei,
Masaru Suzuki,
Hironi Makita,
Satoshi Konno,
Kaoruko Shimizu,
Hironobu Kimura,
Hirokazu Kimura,
Masaharu Nishimura
Publication year - 2019
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s225365
Subject(s) - medicine , copd , exacerbation , gastroenterology , quartile , prospective cohort study , cohort , alpha (finance) , alpha 1 antitrypsin deficiency , cohort study , body mass index , systemic inflammation , vital capacity , inflammation , lung , surgery , confidence interval , diffusing capacity , construct validity , patient satisfaction , lung function
Alpha-1 antitrypsin deficiency is associated with the development of chronic obstructive pulmonary disease (COPD), whereas increased levels of serum alpha-1antitrypsin occur in response to inflammation. The effects of alpha-1 antitrypsin levels on the clinical course of COPD had been unclear. We investigated the association of serum alpha-1 antitrypsin levels with the clinical course of COPD patients based on data from a 10-year prospective cohort study.