Open AccessLong Non-Coding RNA UBA6-AS1 Promotes the Malignant Properties of Glioblastoma by Competitively Binding to microRNA-760 and Enhancing Homeobox A2 Expression
Author(s) -
Feifei Cheng,
Jiang Liu,
Yundong Zhang,
Qian You,
Bin Chen,
Jing Cheng,
Chunyan Deng
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s287676
Subject(s) - competing endogenous rna , gene knockdown , gene silencing , microrna , biology , long non coding rna , antisense rna , cancer research , homeobox , cell growth , rna , carcinogenesis , homeobox a1 , microbiology and biotechnology , transcription factor , cell culture , gene , genetics
The dysregulation of long non-coding RNAs is a frequent finding in glioblastoma (GBM) and is considered as a crucial mechanism contributing to GBM oncogenesis and progression. The biological roles and underlying mechanisms of action of UBA6 antisense RNA 1 (UBA6-AS1) in GBM have been rarely investigated. Therefore, the aim of the present study was to investigate in detail the role of UBA6-AS1 in the modulation of the malignant properties of GBM and explore the possible underlying mechanism(s).