Open AccessDownregulation of MicroRNA-130a Inhibits Oral Squamous Cell Carcinoma Proliferation and Metastasis via the Hippo-YAP Pathway
Author(s) -
Peng Yan,
Shoushan Hu,
Kun Zhang,
Yuru Wang,
Maierdanjiang Rouzi,
Dan Zhou,
Ran Yang
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s287575
Subject(s) - pten , cancer research , hippo signaling pathway , gene silencing , cell growth , downregulation and upregulation , metastasis , microrna , tumor progression , epithelial–mesenchymal transition , biology , pi3k/akt/mtor pathway , signal transduction , microbiology and biotechnology , cancer , gene , biochemistry , genetics
Oral squamous cell carcinoma (OSCC) means oral epithelial cell injury caused by multiple genetic mutations of the cells. Dysregulation of microRNAs (miRs) can disrupt the progression of OSCC. This study explored the mechanism of miR-130a in OSCC progression.