Open AccessCirc_LDLR Knockdown Suppresses Progression of Hepatocellular Carcinoma via Modulating miR-7/RNF38 Axis
Author(s) -
Yuming Jia,
Shengchao Li,
Meng Zhang,
Zhilei Zhang,
Chao Wang,
Chong Zhang,
Wuhan Yang,
Li Peng,
Zhuo Xu
Publication year - 2021
Publication title -
cancer management and research
Language(s) - Uncategorized
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s275003
Subject(s) - ldl receptor , gene knockdown , cancer research , cell growth , viability assay , flow cytometry , microrna , chemistry , cell cycle , apoptosis , hepatocellular carcinoma , cell , biology , microbiology and biotechnology , lipoprotein , biochemistry , cholesterol , gene
Hepatocellular carcinoma (HCC) is a horrible malignancy derived from liver. Circular RNAs (circRNAs) act important roles in the pathogenesis and progression of human diseases, including HCC. The current assay intended to investigate the function of circRNA low-density lipoprotein receptor (circ_LDLR) in HCC and clarify the underlying mechanism.