Long Noncoding RNA VPS9D1-AS1 Sequesters microRNA-525-5p to Promote the Oncogenicity of Colorectal Cancer Cells by Upregulating HMGA1 | Zendy

Hairui Liu | Zendy; Xueying Zhang | Zendy; Xianmei Jin | Zendy; Yubo Yang | Zendy; Guodong Liang | Zendy; Yuehan Ma | Zendy; Bing Wang | Zendy

Open Access

<p>Long Noncoding RNA VPS9D1-AS1 Sequesters microRNA-525-5p to Promote the Oncogenicity of Colorectal Cancer Cells by Upregulating HMGA1</p>

Author(s) -

Hairui Liu,

Xueying Zhang,

Xianmei Jin,

Yubo Yang,

Guodong Liang,

Yuehan Ma,

Bing Wang

Publication year - 2020

Publication title -

cancer management and research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.024

H-Index - 40

ISSN - 1179-1322

DOI - 10.2147/cmar.s273687

Subject(s) - gene silencing , microrna , biology , cell growth , long non coding rna , cancer research , competing endogenous rna , rna interference , antisense rna , downregulation and upregulation , rna , cell culture , microbiology and biotechnology , gene , genetics

The long noncoding RNA VPS9D1 antisense RNA 1 (VPS9D1-AS1) has emerged as a critical regulator in non-small-cell lung, gastric, and prostate cancers. In this study, we measured the expression levels of VPS9D1-AS1 in colorectal cancer (CRC) and determined the role of VPS9D1-AS1 in regulating the biological activities of CRC cells. In addition, we thoroughly elucidated the molecular mechanism mediating the oncogenic activities of VPS9D1-AS1 in CRC.

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