Open Access<p>Long Noncoding RNA VPS9D1-AS1 Sequesters microRNA-525-5p to Promote the Oncogenicity of Colorectal Cancer Cells by Upregulating HMGA1</p>
Author(s) -
Hairui Liu,
Xueying Zhang,
Xu Jin,
Yubo Yang,
Guodong Liang,
Yuehan Ma,
Bing Wang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s273687
Subject(s) - gene silencing , microrna , biology , cell growth , long non coding rna , cancer research , competing endogenous rna , rna interference , antisense rna , downregulation and upregulation , rna , cell culture , microbiology and biotechnology , gene , genetics
The long noncoding RNA VPS9D1 antisense RNA 1 (VPS9D1-AS1) has emerged as a critical regulator in non-small-cell lung, gastric, and prostate cancers. In this study, we measured the expression levels of VPS9D1-AS1 in colorectal cancer (CRC) and determined the role of VPS9D1-AS1 in regulating the biological activities of CRC cells. In addition, we thoroughly elucidated the molecular mechanism mediating the oncogenic activities of VPS9D1-AS1 in CRC.