Open AccessSHP-2 Interacts with CD81 and Regulates the Malignant Evolution of Colorectal Cancer by Inhibiting Epithelial–Mesenchymal Transition
Author(s) -
Huaqin Yuan,
Jun Zhao,
Yang Yang,
Wei RongFu,
Lin-Fan Zhu,
Jie Wang,
M. D. Ding,
Mingyun Wang,
Yanhong Gu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s270813
Subject(s) - colorectal cancer , cancer research , cancer , epithelial–mesenchymal transition , metastasis , apoptosis , cell growth , cancer cell , chemistry , biology , medicine , biochemistry
Colon cancer is a common malignant tumor of the digestive system. This project verified the negative role of protein tyrosine phosphatase (SHP-2) in the regulation of colon cancer and further clarified the key targets and molecular mechanisms in the regulation process.