Open AccessLong Non-Coding RNA ZNF667-AS1 Knockdown Curbs Liver Metastasis in Acute Myeloid Leukemia by Regulating the microRNA-206/AKAP13 Axis
Author(s) -
Nan Wang,
Yanping Feng,
Jinye Xie,
Hui Han,
Qian Dong,
Weijia Wang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s269258
Subject(s) - gene knockdown , cancer research , myeloid leukemia , microrna , carcinogenesis , downregulation and upregulation , biology , metastasis , cell growth , antisense rna , wnt signaling pathway , long non coding rna , gene silencing , cell culture , rna , signal transduction , microbiology and biotechnology , cancer , biochemistry , genetics , gene
Zinc finger protein 667-antisense RNA 1 ( ZNF667-AS1 ), a long non-coding RNA (lncRNA), plays important parts in tumorigenesis and development of esophageal squamous cell carcinoma, but its function in acute myeloid leukemia (AML) is unknown. Our goal here was to probe the functional mechanism of ZNF667-AS1 in AML by mediating microRNA-206 ( miR-206 )/A-kinase anchoring protein 13 ( AKAP13 ) axis.