Open Access<p>Long Non-Coding RNA LINC00491 Contributes to the Malignancy of Non-Small-Cell Lung Cancer via Competitively Binding to microRNA-324-5p and Thereby Increasing Specificity Protein 1 Expression</p>
Author(s) -
Xiaoning Zhang,
Xia Zhao,
Yanqing Wang,
Lijuan Xing
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s264681
Subject(s) - microrna , gene knockdown , cancer research , biology , cell growth , oncogene , long non coding rna , flow cytometry , rna , cell , competing endogenous rna , lung cancer , cell culture , microbiology and biotechnology , cell cycle , gene , medicine , oncology , biochemistry , genetics
A long non-coding RNA termed as long intergenic non-protein coding RNA 491 (LINC00491) has been validated as an oncogene to promote cancer progression in colon adenocarcinoma. The goal of this study was to determine the expression and carcinogenic functions of LINC00491 in non-small-cell lung cancer (NSCLC). Besides, it was aimed to understand how LINC00491 affects the malignant processes of NSCLC cells.