Open Access<p>Long Noncoding RNA PRR34-AS1 Aggravates the Progression of Hepatocellular Carcinoma by Adsorbing microRNA-498 and Thereby Upregulating FOXO3</p>
Author(s) -
Zhaoming Liu,
Zhen Li,
Bo Xu,
Hao Yao,
Shuangyu Qi,
Jianxiong Tai
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s263619
Subject(s) - gene knockdown , foxo3 , cell growth , long non coding rna , cancer research , microrna , cell culture , biology , flow cytometry , competing endogenous rna , cell , apoptosis , antisense rna , microbiology and biotechnology , rna , signal transduction , gene , protein kinase b , biochemistry , genetics
Long noncoding RNAs are differentially expressed in hepatocellular carcinoma (HCC) and have been validated as essential regulators in HCC. However, there is limited knowledge regarding the detailed roles and mechanisms of most lncRNAs in HCC cells. In this study, the expression profiles of PRR34 antisense RNA 1 ( PRR34-AS1 ) in HCC tissues and cell lines were determined. In addition, the detailed roles and underlying mechanisms of PRR34-AS1 in HCC cells were comprehensively elucidated.