Open Access<p>SRF Potentiates Colon Cancer Metastasis and Progression in a microRNA-214/PTK6-Dependent Manner</p>
Author(s) -
Tao Li,
Yingchun Wan,
Ziyuan Su,
Jiayu Li,
Minna Han,
Changyu Zhou
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s257422
Subject(s) - metastasis , cancer research , microrna , stat3 , serum response factor , biology , transcription factor , cell growth , cell migration , cancer , cell culture , microbiology and biotechnology , signal transduction , gene , biochemistry , genetics
Serum response factor (SRF), a sequence-specific transcription factor, is closely related to metastasis of gastric cancer, a digestive tract cancer. Herein, we probed the effect of SRF on metastasis and progression of colon cancer (CC), another digestive tract disorder, and the detailed mechanism.