Open Access<p>MiR-138-5p Inhibits the Proliferation of Gastric Cancer Cells by Targeting DEK</p>
Author(s) -
Wei Zhang,
Kai Liao,
Dongning Liu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s253777
Subject(s) - oncogene , cell growth , cell cycle , apoptosis , microrna , cancer research , cancer , cell cycle checkpoint , cell , biology , cell culture , metastasis , chemistry , biochemistry , gene , genetics
Increasing evidence suggests that microRNAs (miRNAs) play critical roles in cancer progression. Therefore, investigating the function of miRNAs that are aberrantly expressed in gastric cancer (GC) and characterizing the involved underlying mechanism are essential for the treatment of gastric cancer. MiR-138-5p was found to be down-regulated in multiple cancers, which acted as a tumor suppressor in cancer progression; however, whether and how miR-138-5p regulates the malignant behaviors of GC has not been fully understood.