Open Access<p>Modulation of MnSOD and FoxM1 Is Involved in Invasion and EMT Suppression by Isovitexin in Hepatocellular Carcinoma Cells</p>
Author(s) -
Yebei Qiu,
Xiaocheng Cao,
Lihua Liu,
Xiaozheng Cao,
Qing Yuan,
Xiang Li,
Yinghong Cui,
Chong Xu,
Chang Zou,
Kai Ren,
Ji Cao
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s245283
Subject(s) - foxm1 , gene knockdown , downregulation and upregulation , cancer research , biology , gentamicin protection assay , thiostrepton , epithelial–mesenchymal transition , chemistry , cell culture , metastasis , cancer , biochemistry , genetics , gene , ribosome , rna
Manganese superoxide dismutase (MnSOD) induces FoxM1 expression, subsequently contributing to migration in several cancer cells. Isovitexin (ISOV) was recently found to downregulate MnSOD and FoxM1, decreasing stemness in hepatocellular carcinoma (HCC) stem-like cells (HCSLCs). The current study aimed to determine whether inhibition of migration, invasion and EMT in HCSLCs by ISOV results from MnSOD/FoxM1 signaling blockade and subsequent Twist1, Slug, ZEB1 and MMP-2 downregulation.