Open Access<p>Hypoxia-Induced Aquaporin-3 Changes Hepatocellular Carcinoma Cell Sensitivity to Sorafenib by Activating the PI3K/Akt Signaling Pathway</p>
Author(s) -
Kija Malale,
Jili Fu,
Liewang Qiu,
Ke Zhan,
Xiuni Gan,
Zhechuan Mei
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s243918
Subject(s) - sorafenib , aquaporin 3 , pi3k/akt/mtor pathway , apoptosis , transfection , protein kinase b , blot , cell growth , chemistry , cancer research , mapk/erk pathway , flow cytometry , microbiology and biotechnology , hepatocellular carcinoma , cell culture , biology , signal transduction , aquaporin , biochemistry , genetics , gene
Hypoxia-induced changes are primarily activated in patients with hepatocellular carcinoma (HCC) and long-term sorafenib exposure, thereby reducing the sensitivity to the drug. Aquaporin-3 (AQP3), a member of the aquaporin family, is a hypoxia-induced substance that affects the chemosensitivity of non-hepatocellular tumors. However, its expression and role in the sensitivity of hypoxic HCC cells to sorafenib-induced apoptosis remain unclear. The purpose of this study was to detect changes in AQP3 expression in hypoxic HCC cells and to determine whether these changes alter the sensitivity of these cells to sorafenib.