Open Access<p>Clinical Significance of Down-Regulated CD70 and CD27 Expression in Poor Prognosis of Esophageal Squamous Cell Carcinoma</p>
Author(s) -
Tingting Shan,
Xuan Zhao,
Zhen Zhang,
Jingpu Wang,
Yi Zhang,
Yang Yang,
Song Zhao
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s241377
Subject(s) - cxcl9 , cancer research , cd8 , immune system , immune checkpoint , biology , chemokine receptor , chemokine , immunology , immunotherapy
CD27 is a co-stimulatory immune checkpoint molecule in the tumor necrosis factor receptor superfamily. CD27 regulates the generation and maintenance of T cell immunity by binding to CD70 and regulating B-cell activation and immunoglobulin synthesis.