Open Access<p>Long Non-coding RNA BLACAT1 Induces Tamoxifen Resistance in Human Breast Cancer by Regulating miR-503/Bcl-2 Axis</p>
Author(s) -
Rongfeng Qu,
Chunmei Hu,
Yan Tang,
Qiong Yu,
Guang Shi
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s239981
Subject(s) - gene knockdown , apoptosis , downregulation and upregulation , breast cancer , long non coding rna , mtt assay , cancer research , microbiology and biotechnology , western blot , biology , cell growth , cancer , gene , genetics
At present, drug resistance remains a major obstacle for breast cancer (BCa) patients who receive tamoxifen (TAM) chemotherapy. In this study, we aimed to investigate the functional role of long non-coding RNA BLACAT1 in the acquisition of TAM resistance in BCa.