Open Access<p>miR-489-3p Inhibits Prostate Cancer Progression by Targeting DLX1</p>
Author(s) -
Peide Bai,
Wei Li,
Zhenghua Wan,
Yujuan Xiao,
Wen Xiao,
Xuegang Wang,
Zhun Wu,
Kaiyan Zhang,
Yongfeng Wang,
Bin Chen,
Jinchun Xing,
Tao Wang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s239796
Subject(s) - du145 , prostate cancer , cancer research , microrna , cell cycle , cell growth , biology , cancer , apoptosis , flow cytometry , metastasis , oncogene , lncap , microbiology and biotechnology , gene , genetics
Prostate cancer (PCa) is the third most common cancer in men and the second leading cause of cancer-related death in men. DLX1 belongs to the DLX homeobox family and exhibits antitumor activity in many kinds of tumors. MicroRNAs (miRNAs) play important roles in the progression of cancer. However, whether miRNAs affect the development of PCa by targeting DLX1 has not been determined. In this study, we aimed to investigate the role of miR-489-3p in the regulation of DLX1 expression and PCa progression and to provide a potential therapeutic target for PCa treatment.