Open Access<p>Down-regulation of CCL17 in cancer-associated fibroblasts inhibits cell migration and invasion of breast cancer through ERK1/2 pathway</p>
Author(s) -
Junjie Li,
Yang Chen,
Jingshi Yang,
Liqun Zou
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s211651
Subject(s) - ccl17 , cancer research , tumor microenvironment , cancer associated fibroblasts , stromal cell , chemistry , microbiology and biotechnology , chemokine , medicine , chemokine receptor , biology , receptor , biochemistry , tumor cells
Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are involved in cancer development and progression, including breast cancer (BC). Up-regulation of CCL17 was observed in BC and predicted a decrease in overall survival, suggesting an important role of CCL17 in BC development. Nonetheless, little is known about the role of CCL17 in the interaction between CAFs and BC.