Open Access<p>OSM-induced CD44 contributes to breast cancer metastatic potential through cell detachment but not epithelial-mesenchymal transition</p>
Author(s) -
Hunter Covert,
Liliana F. Mellor,
Cody Wolf,
Nicole Ankenbrandt,
Jacqueline Emathinger,
Ken Tawara,
Julia Thom Oxford,
Cheryl L. Jorcyk
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s208721
Subject(s) - cd44 , cancer research , epithelial–mesenchymal transition , metastasis , cancer cell , estrogen receptor , cell migration , cell , medicine , breast cancer , chemistry , cancer , biology , biochemistry
Hormone receptor status in human breast cancer cells is a strong indicator of the aggressiveness of a tumor. Triple negative breast cancers (TNBC) are aggressive, difficult to treat, and contribute to high incidences of metastasis by possessing characteristics such as increased tumor cell migration and a large presence of the transmembrane protein, cluster of differentiation 44 (CD44) on the cell membrane. Estrogen receptor-positive (ER+) cells are less aggressive and do not migrate until undergoing an epithelial-mesenchymal transition (EMT).