Open Access<p>Human Adipose Tissue-Derived Mesenchymal Stem Cells in Parkinson’s Disease: Inhibition of T Helper 17 Cell Differentiation and Regulation of Immune Balance Towards a Regulatory T Cell Phenotype</p>
Author(s) -
Yonghong Bi,
Xiaolan Lin,
Huazheng Liang,
Dehao Yang,
Xiaowei Zhang,
Jianming Ke,
Jingjing Xiao,
Zhilin Chen,
Weian Chen,
Xu Zhang,
Yilong Wang,
Chunfeng Liu
Publication year - 2020
Publication title -
clinical interventions in aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 76
eISSN - 1178-1998
pISSN - 1176-9092
DOI - 10.2147/cia.s259762
Subject(s) - foxp3 , il 2 receptor , rar related orphan receptor gamma , regulatory t cell , medicine , immune system , mesenchymal stem cell , adipose tissue , immunology , t cell , cancer research , interleukin 21 , cellular differentiation , peripheral blood mononuclear cell , microbiology and biotechnology , biology , endocrinology , in vitro , biochemistry , gene
Parkinson's disease (PD) is a neurodegenerative disorder displaying a typical neuroinflammation pathology that may result from an imbalance between regulatory T cells (Treg) and T helper 17 (Th17) cells. Human adipose tissue-derived mesenchymal stem cells (Ad-MSCs) exert immunomodulatory effects by inhibiting effector T cell responses and have been used to treat diverse immune disorders. We aimed to investigate the modulating effect of human Ad-MSCs on peripheral blood mononuclear cells (PBMCs) of patients with PD, focusing on differentiation into Th17 and Treg cells.