Open AccessEffects of Trial Population Selection on Quality of Life and Healthcare Decision-Making: A Systematic Review and Example in the Treatment of Hepatocellular Carcinoma with Radioembolization
Author(s) -
Richard F. Pollock,
Fabien Colaone,
Suki Shergill,
Victoria K Brennan,
Ion Agirrezabal
Publication year - 2021
Publication title -
clinicoeconomics and outcomes research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.591
H-Index - 27
ISSN - 1178-6981
DOI - 10.2147/ceor.s319857
Subject(s) - medicine , quality of life (healthcare) , psychological intervention , systematic review , population , quality adjusted life year , cochrane library , cost effectiveness , economic evaluation , clinical trial , medline , intensive care medicine , randomized controlled trial , oncology , environmental health , pathology , risk analysis (engineering) , nursing , psychiatry , political science , law
Quality of life is among the most important considerations in the treatment of hepatocellular carcinoma (HCC), arguably second only to overall survival. Measuring and modeling patient quality of life is also crucial in the evaluation of the cost-effectiveness of health interventions. In the present study, we aimed to identify cost-utility analyses comparing selective internal radiation therapy (SIRT) with systemic therapy in patients with unresectable HCC and to compare the modeled incremental quality of life differences between the two therapies.