Open AccessNonalcoholic Fatty Liver Disease and Chronic Kidney Disease: A Review of Links and Risks
Author(s) -
Amanda Cheung,
Aijaz Ahmed
Publication year - 2021
Publication title -
clinical and experimental gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 30
ISSN - 1178-7023
DOI - 10.2147/ceg.s226130
Subject(s) - medicine , nonalcoholic fatty liver disease , kidney disease , disease , metabolic syndrome , diabetes mellitus , obesity , incidence (geometry) , type 2 diabetes , chronic liver disease , fatty liver , intensive care medicine , bioinformatics , endocrinology , cirrhosis , physics , optics , biology
Nonalcoholic fatty liver disease and chronic kidney disease are both chronic conditions with rapidly increasing prevalence and incidence worldwide that have led to a significant burden on health-care systems. The association between these two disease entities is partly attributed to shared cardiometabolic comorbidities including diabetes, hypertension, obesity, and metabolic syndrome. However, independent of these overlapping risks, there are increased rates and more severe CKD in NAFLD patients. Conversely, more progressive NAFLD is seen with advanced stages of kidney injury. In addition to overlapping risk factors, shared pathogenic mechanisms suggest these two disease entities may resemble different manifestations of a single underlying disease process.