Open Access<p>Honey and Chamomile Activate Keratinocyte Antioxidative Responses via the KEAP1/NRF2 System</p>
Author(s) -
Tatsuya Ogawa,
Yosuke Ishitsuka,
Yoshiyuki Nakamura,
Naoko Okiyama,
Rei Watanabe,
Yasuhiro Fujisawa,
Manabu Fujimoto
Publication year - 2020
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s270602
Subject(s) - keap1 , stratum corneum , keratinocyte , epidermis (zoology) , antioxidant , chemistry , microbiology and biotechnology , biochemistry , biology , transcription factor , in vitro , anatomy , genetics , gene
The stratum corneum protects against the entry of pathogens, allergens, and irritants while preventing dehydration. The Kelch-like erythroid cell-derived protein with cap-n-collar homology-associated protein 1 (KEAP1)/NF-E2-related factor 2 (NRF2) system maintains skin barrier homeostasis. Aggregated evidence suggests that NRF2-mediated antioxidative response is hardwired into the stratified squamous epithelia. Honey and chamomile have long been regarded as natural antioxidants. Nonetheless, it is still unclear whether they activate the KEAP1/NRF2 system in the epidermis and could promote epidermal barrier recovery.