Open AccessHospitalization requiring intensive care unit due to SARS-CoV-2 infection correlated with IgM depression and IgG elevation
Author(s) -
Sara Tamizuddin,
Jason Cham,
Yasamin Ghiasi,
Luis Borroto,
Cindy Cao,
Natalia Orendain,
Michael Quigley,
Laura Nicholson,
Amitabh C. Pandey
Publication year - 2022
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2021-0126
Subject(s) - medicine , intensive care unit , antibody , immunology , depression (economics) , covid-19 , immunoglobulin g , intensive care , disease , intensive care medicine , infectious disease (medical specialty) , economics , macroeconomics
Aim: This study investigated the humoral response against SARS-CoV-2 in patients needing intensive care unit (ICU) care compared with those on general medicine wards. Materials & methods: The authors retrospectively reviewed 113 hospitalized patients with COVID-19. They assessed antibody response against five SARS-CoV-2 epitopes at 6–14 days post symptom onset in these patients. Results: Patients with ICU admissions had decreased anti-nucleocapsid immunoglobulin (Ig)M and increased anti-spike IgG compared with patients not requiring the ICU. IgG levels were positively correlated with length of stay. Conclusion: Higher levels of IgG against the spike protein correlate with COVID-19 disease severity and length of stay in hospitalized patients. This adds to the knowledge of biochemical response to clinical disease and may help predict ICU needs.