Hyperacute Transplantation of Umbilical Cord Mesenchymal Stromal Cells in a Model of Severe Intracerebral Hemorrhage | Zendy

Tanira Giara Mello | Zendy; Paulo Henrique Rosado-de-Castro | Zendy; Juliana Ferreira Vasques | Zendy; Carolina Pinhão | Zendy; Tayna Santos | Zendy; Renata Rodrigues de Lima | Zendy; Bernd Foerster | Zendy; Fernando Fernandes Paiva | Zendy; Rosalia MéndezOtero | Zendy; Pedro M. PimentelCoelho | Zendy

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Hyperacute Transplantation of Umbilical Cord Mesenchymal Stromal Cells in a Model of Severe Intracerebral Hemorrhage

Author(s) -

Tanira Giara Mello,

Paulo Henrique Rosado-de-Castro,

Juliana Ferreira Vasques,

Carolina Pinhão,

Tayna Santos,

Renata Rodrigues de Lima,

Bernd Foerster,

Fernando Fernandes Paiva,

Rosalia MéndezOtero,

Pedro M. PimentelCoelho

Publication year - 2022

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.2144/fsoa-2021-0121

Subject(s) - mesenchymal stem cell , umbilical cord , medicine , transplantation , stromal cell , intracerebral hemorrhage , animal model , cord lining , pathology , biology , surgery , immunology , adult stem cell , endothelial stem cell , in vitro , biochemistry , subarachnoid hemorrhage

Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a moderate hemorrhage but was inefficient in severe ICH. Here, we investigated whether a treatment in the hyperacute phase would be more effective in severe ICH. Materials & methods: Wistar rats were randomly selected to receive an intravenous injection of hUC-MSC or the vehicle 1 h after a severe ICH. Results: The hyperacute treatment with hUC-MSC did not affect the 22-day survival rate, the motor function or the residual hematoma volume. Conclusion: These results indicate the need for optimization of hUC-MSC-based therapies for severe ICH.

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