Open AccessHyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage
Author(s) -
Tanira Giara Mello,
Paulo Henrique Rosado-de-Castro,
Juliana Ferreira Vasques,
Carolina Pinhão,
Tayna Santos,
Renata Rodrigues de Lima,
Bernd Foerster,
Fernando Fernandes Paiva,
Rosália Mendez-Otero,
Pedro M. PimentelCoelho
Publication year - 2022
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2021-0121
Subject(s) - medicine , intracerebral hemorrhage , mesenchymal stem cell , umbilical cord , hematoma , transplantation , stromal cell , surgery , anesthesia , pathology , immunology , glasgow coma scale
Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a moderate hemorrhage but was inefficient in severe ICH. Here, we investigated whether a treatment in the hyperacute phase would be more effective in severe ICH. Materials & methods: Wistar rats were randomly selected to receive an intravenous injection of hUC-MSC or the vehicle 1 h after a severe ICH. Results: The hyperacute treatment with hUC-MSC did not affect the 22-day survival rate, the motor function or the residual hematoma volume. Conclusion: These results indicate the need for optimization of hUC-MSC-based therapies for severe ICH.